Lancet 1995; 345: 199–200, Sanna A, Kurtansky A, Veriter C, Stanescu D: Bronchodilator effect of inhaled nitric oxide in healthy men. NIH Stereoselective S-nitrosothiol recognition sites. J Appl Physiol 1993; 74: 1704–11, Pison U, Lopez FA, Heidelmeyer CF, Rossaint R, Falke KJ: Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange. Am J Respir Crit Care Med 1998; 158: 931–8, Kermarrec N, Chollet-Martin S, Beloucif S, Faivre V, Gougerot-Pocidalo MA, Payen DM: Alveolar neutrophil oxidative burst and β, Biffl WL, Moore EE, Moore FA, Barnett C: Nitric oxide reduces endothelial expression of intercellular adhesion molecule (ICAM)-1. Am J Physiol 1995; 269: H473–9, Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarke WR, Abman SH: Dipyridamole potentiates pulmonary vasodilation induced by acetylcholine and nitric oxide in the ovine fetus. Anatomic and physiologic correlates. J Cyclic Nucleotide Res 1979; 5: 211–24, Ignarro LJ, Degnan JN, Baricos WH, Kadowitz PJ, Wolin MS: Activation of purified guanylate cyclase by nitric oxide requires heme. J Pediatr 1998; 132: 827–9, Luhr O, Aardal S, Nathorst-Westfelt U, Berggren L, Johansson LA, Wahlin L, Frostell C: Pulmonary function in adult survivors of severe acute lung injury treated with inhaled nitric oxide. Adhikari NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO. Nitric oxide (NO) is a naturally occurring vasodilator produced by vascular endothelial cells. J Thorac Cardiovasc Surg 1996; 111: 753–62, Auler Junior JO, Carmona MJ, Bocchi EA, Bacal F, Fiorelli AI, Stolf NA, Jatene AD: Low doses of inhaled nitric oxide in heart transplant recipients. NLM Nitric oxide is produced by many cell types in the lung and plays an important physiologic role in the regulation of pulmonary vasomotor tone by several known mechanisms. A NESTHESIOLOGY 1995; 82: 1507–11, Adrie C, Ichinose F, Holzmann A, Keefer L, Hurford WE, Zapol WM: Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension. 2 Inhaled nitric oxide and … Am J Respir Crit Care Med 1994; 150: 233–7, Lindeman KS, Aryana A, Hirshman CA: Direct effects of inhaled nitric oxide on canine peripheral airways. J Clin Invest 1998; 101: 2468–77, Ravichandran LV, Johns RA, Rengasamy A: Direct and reversible inhibition of endothelial nitric oxide synthase by nitric oxide. Inhaling through the mouth may not accomplish this. Neuroscience 1993; 54: 839–43, Watkins DN, Peroni DJ, Basclain KA, Garlepp MJ, Thompson PJ: Expression and activity of nitric oxide synthases in human airway epithelium. Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Am J Pathol 1985; 121: 212–23, Jones R, Adler C, Farber F: Lung vascular cell proliferation in hyperoxic pulmonary hypertension and on return to air:[, Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB: Nitric oxide (NO) protects against cellular damage by reactive oxygen species. In this study, a benefit of decreased duration of mechanical ventilation and an increased rate of ECMO-free survival was demonstrated in patients who were randomized to receiving iNO, suggesting that there may be benefit to the use of iNO in pediatric ARDS (PARDS) that has not been demonstrated in adults. Eur J Pharmacol 1980; 61: 125–36, Gillart T, Bazin JE, Cosserant B, Guelon D, Aigouy L, Mansoor O, Schoeffler P: Combined nitric oxide inhalation, prone positioning and almitrine infusion improve oxygenation in severe ARDS. Nitric oxide is a potent vasodilator which when inhaled causes dilatation in the pulmonary vasculature. Several studies have suggested that iNO improves oxygenation, particularly in trials of term and near-term neonates with hypoxic respiratory failure. Crit Care Med 1997; 25: 584–93, Weinberger B, Fakhrzadeh L, Heck DE, Laskin JD, Gardner CR, Laskin DL: Inhaled nitric oxide primes lung macrophages to produce reactive oxygen and nitrogen intermediates. Biochem Biophys Res Commun 1993; 195: 539–44, Darley-Usmar VM, Hogg N, O'Leary VJ, Wilson MT, Moncada S: The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. Chest 1996; 109: 486–93, Holzmann A, Bloch KD, Sanchez LS, Filippov G, Zapol WM: Hyporesponsiveness to inhaled nitric oxide in isolated, perfused lungs from endotoxin-challenged rats. This site needs JavaScript to work properly. Ann Thorac Surg 1996; 62: 750–5, Fullerton DA, Jones SD, Jaggers J, Piedalue F, Grover FL, McIntyre RC Jr: Effective control of pulmonary vascular resistance with inhaled nitric oxide after cardiac operation. By delivering nitric oxide directly to the desired site of action (i.e., the pulmonary arterioles), inhaled nitric oxide can preferentially dilate the pulmonary vasculature while minimizing the effects on systemic arterial tone. Mechanism of Action and Inaction of Inhaled Nitric Oxide. N Engl J Med (2000) 342(7):469–74.10.1056/NEJM200002173420704 Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome. Circ Res 1996; 79: 984–91, Nadaud S, Philippe M, Arnal JF, Michel JB, Soubrier F: Sustained increase in aortic endothelial nitric oxide synthase expression in vivo in a model of chronic high blood flow. During the past 8 yr, inhaled NO has been used to treat pulmonary hypertension and hypoxemia in thousands of patients worldwide. Barrington KJ, Finer N, Pennaforte T, Altit G. Cochrane Database Syst Rev. Nitric oxide, the active substance in INOmax, is a pulmonary vasodilator. 2017;967:105-137. doi: 10.1007/978-3-319-63245-2_8. A NESTHESIOLOGY 1997; 86: 895–902, Grover FL, Fullerton DA, Zamora MR, Mills C, Ackerman B, Badesch D, Brown JM, Campbell DN, Chetham P, Dhaliwal A, Diercks M, Kinnard T, Niejadlik K, Ochs M: The past, present, and future of lung transplantation. 156,157 The expression of various NOS isoforms in peripheral nonadrenergic noncholinergic nerve endings 158 and in human bronchial epithelium 159 supports this finding. Am J Physiol 1996; 271: H2045–51, Chen LY, Mehta JL: Downregulation of nitric oxide synthase activity in human platelets by nitroglycerin and authentic nitric oxide. Most importantly, randomized multicenter studies of NO inhalation have shown that this new therapy significantly reduces the necessity for ECMO in newborns with PPHN or hypoxic respiratory failure. Nitric oxide may also regulate pulmonary vasodilation by direct activation of K+ channels or by modulating the expression and activity of angiotensin II receptors. Endothelial NOS and neuronal NOS are constitutively expressed and regulated by calcium fluctuations. 8. -, Afshari A, Brok J, Møller AM, Wetterslev J. Proc Natl Acad Sci U S A 1987; 84: 9265–9, Altman LK: Three americans awarded nobel for discoveries of how a gas affects the body. [2:12] Eur Respir J 1993; 6: 177–80, Brown RH, Zerhouni EA, Hirshman CA: Reversal of bronchoconstriction by inhaled nitric oxide. Respir Care 1999; (in press), Meyrick B, Reid L: Pulmonary hypertension. Am Rev Respir Dis 1992; 145: 291–300, Stephens RJ, Freeman G, Evans MJ: Early response of lungs to low levels of nitrogen dioxide. Am J Respir Cell Mol Biol 1998; 18: 421–8, Meyrick B, Reid L: The effect of continued hypoxia on rat pulmonary arterial circulation. As with most medical advances, it is the evolution of a wide-ranging body of research that will properly determine the place for NO inhalation therapy in our armamentarium. Vision Res 1996; 36: 2979–94, Vallance P, Moncada S: Role of endogenous nitric oxide in septic shock. Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism. Avoiding ECMO, a complicated and expensive invasive procedure with limited availability, is an important clinical endpoint and undoubtedly would justify the use of inhaled NO. Surgery 1994; 116: 313–21, Dahm P, Blomquist S, Martensson L, Thorne J, Zoucas E: Circulatory and ventilatory effects of intermittent nitric oxide inhalation during porcine endotoxemia. Ann Thorac Surg 1997; 63: 345–51, Bacha EA, Sellak H, Murakami S, Mazmanian GM, Detruit H, de Montpreville V, Chapelier AR, Libert JM, Dartevelle PG, Herve P: Inhaled nitric oxide attenuates reperfusion injury in non- heartbeating-donor lung transplantation. 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J Leukoc Biol 1993; 53: 165–72, Stadler J, Trockfeld J, Schmalix WA, Brill T, Siewert JR, Greim H, Doehmer J: Inhibition of cytochromes P4501A by nitric oxide. Am J Physiol 1994; 267: H1955–61, Fratacci MD, Frostell CG, Chen TY, Wain JC Jr, Robinson DR, Zapol WM: Inhaled nitric oxide. Stroke 1997; 28: 1283–8, Fukumura D, Jain RK: Role of nitric oxide in angiogenesis and microcirculation in tumors. J Pediatr 1997; 130: 225–30, Rossaint R, Slama K, Steudel W, Gerlach H, Pappert D, Veit S, Falke K: Effects of inhaled nitric oxide on right ventricular function in severe acute respiratory distress syndrome. Gebistorf F, Karam O, Wetterslev J. Cochrane Database Syst Rev response... 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